Analytical Data
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基因名
NCAM-1/CD56
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简介
Neural cell adhesion molecule 1 (NCAM1) is a cell adhesion molecule which enables LRR domain binding activity and phosphatase binding activity. NCAM1 plays a role in the cell development and differentiation as well as immune surveillance. NCAM1 plays a role in signal transduction by interacting with fibroblast growth factor receptors, N-cadherin and activating FAK, MAPK and PI3K. NCAM-1/CD56 Protein, Human (699a.a, HEK293, Llama Fc) is the recombinant human-derived NCAM-1/CD56 protein, expressed by HEK293, with C-Llama Fc labeled tag.
- Application
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别名
CD56; NCAM-1; CD56 antigen; MSK39; N-CAM-1; NCAM-1; neural cell adhesion molecule 1; neural cell adhesion molecule; NCAM
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种属
Human
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表达系统
HEK293
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标签
C-Llama Fc
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P13591-2
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表达区间
L20-G718
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分子量
130-150 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
NCAM-1 (Neural Cell Adhesion Molecule 1) and CD56 (also known as neural cell adhesion molecule or NCAM) are important cell adhesion molecules involved in various biological processes, including nervous system development, immune response, and cellular signaling. NCAM-1, primarily expressed in the nervous system, plays a crucial role in neuron-neuron and neuron-glia interactions, influencing neuronal survival, differentiation, and migration. CD56 is widely recognized for its expression on natural killer (NK) cells, where it contributes to their activation and function in immune responses. The study of NCAM-1/CD56 recombinant proteins has gained traction due to their potential applications in both therapeutic and diagnostic contexts. By generating and characterizing these recombinant proteins, researchers aim to elucidate their roles in cell adhesion and signaling pathways, which may contribute to understanding various diseases, including neurodegenerative disorders and cancers. Furthermore, exploring NCAM-1/CD56 interactions may reveal new targets for immunotherapy, particularly in optimizing NK cell responses against tumors. Thus, the investigation of NCAM-1/CD56 recombinant proteins is vital for advancing our understanding of fundamental biological mechanisms and developing innovative therapeutic strategies.
