Analytical Data
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基因名
FGL2
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简介
FGL2 is a key enzyme in the coagulation cascade and plays a key role in the conversion of prothrombin to thrombin, reflecting its important contribution to hemostasis and coagulation processes. Structurally, FGL2 forms homotetramers characterized by disulfide bonds that contribute to its functional integrity and catalytic activity in the complex process of thrombin generation. FGL2 Protein, Mouse (HEK293, His-Avi, Flag) is the recombinant mouse-derived FGL2 protein, expressed by HEK293 , with C-Avi, N-His, N-Flag labeled tag.
- Application
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生物活性
Immobilized Mouse FGL2, His Tag at 5μg/mL (100μL/well) can bind anti-FGL2 Antibody, The ED50 for this effect is 5.068 ng/mL. Immobilized Mouse FGL2, His Tag at 5 μg/mL (100 μL/well) can bind anti-FGL2 Antibody, The ED50 for this effect is 5.068 ng/mL.
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别名
Fibroleukin; pT49; FGL2; fibrinogen-like 2;
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种属
Mouse
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表达系统
HEK293
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标签
C-Avi;N-His;N-Flag
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P12804
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表达区间
P197-P432
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氨基酸序列
PVQHLIYKDCSDHYVLGRRSSGAYRVTPDHRNSSFEVYCDMETMGGGWTVLQARLDGSTNFTREWKDYKAGFGNLEREFWLGNDKIHLLTKSKEMILRIDLEDFNGLTLYALYDQFYVANEFLKYRLHIGNYNGTAGDALRFSRHYNHDLRFFTTPDRDNDRYPSGNCGLYYSSGWWFDSCLSANLNGKYYHQKYKGVRNGIFWGTWPGINQAQPGGYKSSFKQAKMMIRPKNFKP
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蛋白长度
Partial
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分子量
40-50 kDa.
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
FGL2, or fibrinogen-like protein 2, is a member of the fibrinogen-related protein family that has gained attention in the research community due to its significant role in immune regulation and potential implications in various diseases, particularly in cancer and autoimmune disorders. Originally identified as a product of activated T cells, FGL2 is involved in modulating immune responses by interacting with specific receptors, thereby influencing the activity of immune cells such as T cells and macrophages. The understanding of FGL2’s structure and function has led to investigations into its role as a potential biomarker for disease progression and therapeutic target. Research has indicated that FGL2 may promote tumor growth and metastasis in certain cancers by creating an immunosuppressive environment, complicating the host's immune response against tumors. Moreover, its involvement in regulating cytokine production and the balance between Th1 and Th2 responses highlights its importance in maintaining immune homeostasis. Recombining FGL2 into a soluble form for further study has enabled scientists to explore its mechanisms of action in greater detail, paving the way for the development of innovative therapeutic strategies aimed at modulating immune responses. Understanding the biological functions and therapeutic potential of FGL2 could lead to breakthrough advancements in treating various pathologies, underscoring the significance of this protein in both basic and applied biomedical research.
