Analytical Data
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Gene name
C-MPL
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简介
C-MPL Protein, the thrombopoietin receptor, is a pivotal regulator of megakaryopoiesis and platelet production, suggesting a specific role in TPO-R-dependent immune responses. Forming homodimers and interacting with ATXN2L, it contributes to its multifaceted role in hematopoiesis and immune modulation. C-MPL Protein, Human (HEK293, His) is the recombinant human-derived C-MPL protein, expressed by HEK293 , with C-His labeled tag.
- Application
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Alternative Names
TPO-R; CD110; MPL; c-Mpl; MPLV; K12
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Species
Human
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Source
HEK293
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Tag
C-8*His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P40238-1
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Expression Region
Q26-W491
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Protein Length
Extracellular Domain
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Molecular Weight
68-70 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
C-MPL, or c-Mpl, is a critical receptor for thrombopoietin (TPO), a key hormone in the regulation of megakaryocyte and platelet production. Understanding the structure and function of C-MPL is imperative for addressing various hematological disorders, including thrombocytopenia and other platelet-related diseases. Dysregulation of the C-MPL signaling pathway can result in severe conditions, such as myeloproliferative neoplasms or other forms of leukemia. Recent advances in recombinant protein technology have facilitated the production of C-MPL, allowing researchers to study its molecular mechanisms and interactions in detail. By generating recombinant C-MPL proteins, scientists can investigate their role in TPO signaling, receptor dimerization, and downstream signaling cascades. These studies provide insights into how C-MPL operates at the cellular level, paving the way for the development of therapeutic interventions targeting this receptor. Furthermore, recombinant C-MPL can be utilized for the development of diagnostic tools or therapeutic agents, enhancing our understanding of platelet physiology and pathology. As research progresses, the implications of C-MPL in clinical settings continue to expand, underscoring its significance in both basic and translational research.
