Analytical Data
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Gene name
FCRL1
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简介
FCRL1 Protein, a potential activating coreceptor in B-cells, may play a role in B-cell activation and differentiation. Although the precise mechanisms are under investigation, FCRL1's presence suggests involvement in intricate signaling pathways associated with B-cell function and immune responses. FCRL1 Protein, Mouse (Q8R4Y0-2, HEK293, His) is the recombinant mouse-derived FCRL1 protein, expressed by HEK293 , with C-His labeled tag.
- Application
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Alternative Names
Fc receptor-like protein 1; FcRL1; FcRH1; hIFGP1; CD307a; FCRH1; IFGP1; IRTA5
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Species
Mouse
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Source
HEK293
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Tag
C-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8R4Y0-2
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Expression Region
A17-T204
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Protein Length
Partial
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Molecular Weight
42-47 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
FCRL1, or Fc receptor-like 1, is a member of the Fc receptor family, which plays a pivotal role in the immune response regulation, particularly in the context of B cell development and function. Characterized by its unique extracellular features, FCRL1 is predominantly expressed on B cells and has been implicated in modulating T cell activation and antibody responses. Research has increasingly focused on FCRL1’s function in various immunological contexts, including autoimmunity and cancer, as it may influence the balance between tolerance and immune activation. Studies have shown that the expression levels of FCRL1 can vary significantly in different diseases, indicating its potential as a biomarker for disease progression or therapeutic response. Furthermore, understanding the structural dynamics of FCRL1 through recombinant protein studies can provide insights into its receptor-ligand interactions and downstream signaling pathways, paving the way for novel therapeutic strategies. As such, the production and characterization of recombinant FCRL1 protein become crucial for elucidating its functional roles in immunology and for exploring its potential applications in targeted therapies.
