Analytical Data
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Gene name
FcRH5/FcRL5
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简介
FcRH5/FcRL5 Protein, potentially impacting B-cell development and differentiation in peripheral lymphoid organs, serves as a marker for B-cell stages. It may have an immunoregulatory role in marginal zone B-cells and is suggested to play a role in fertilization. FcRH5/FcRL5 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived FcRH5/FcRL5, expressed by HEK293, with N-His, N-Avi labeled tag. The total length of FcRH5/FcRL5 Protein, Human (Biotinylated, HEK293, His-Avi) is 836 a.a..
- Application
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Alternative Names
FcR-like protein 5; FcRH5; FcRL5; BXMAS1; CD307; CD307e; IFGP5
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Species
Human
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Source
HEK293
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Tag
N-Avi;N-8*His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q96RD9-1
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Expression Region
Q16-G851
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Protein Length
Extracellular Domain
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Molecular Weight
90-130 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
FcRH5 (Fc receptor homolog 5) and FcRL5 (Fc receptor-like 5) are members of the Fc receptor family, which play critical roles in immune regulation and antibody-mediated responses. These proteins are predominantly expressed on B cells, where they are implicated in the modulation of immune signaling pathways. Recent studies have shown that FcRH5 is involved in the regulation of B cell activation and differentiation, while FcRL5 is linked to the inhibition of cell activation, contributing to immune tolerance. The interest in these receptors has notably increased due to their potential as targets for novel immunotherapeutic strategies, particularly in cancer treatment and autoimmune diseases. Researchers are investigating the structural and functional aspects of FcRH5 and FcRL5 through recombinant protein techniques, which allow for detailed analysis of their interactions and signaling mechanisms. Understanding the roles of these receptors could provide valuable insights into enhancing immune responses or promoting immune tolerance in various clinical contexts. The exploration of FcRH5 and FcRL5 as therapeutic targets represents a promising avenue in the development of next-generation immunotherapies.
