Analytical Data
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Gene name
TLR3
- Application
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Alternative Names
TLR3; CD283; IIAE2
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Species
Human
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Source
HEK293
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Tag
C-hFc
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q6PCD4
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Expression Region
S23-E703
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Molecular Weight
120-140 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
TLR3, or Toll-like receptor 3, is a critical component of the innate immune system, primarily responsible for recognizing double-stranded RNA, which is often associated with viral infections. Research into TLR3 recombinant proteins has gained momentum due to their potential therapeutic applications in infectious diseases and cancer. Studies show that TLR3 activation can enhance the immune response by inducing the production of pro-inflammatory cytokines and type I interferons, making it a key player in antiviral defenses. Additionally, the ability of TLR3 to modulate immune responses presents opportunities for vaccine development and adjuvant design. Recombinant TLR3 proteins facilitate detailed studies of its functional roles in immune signaling pathways, and they serve as valuable tools for exploring the receptor's interactions with ligands and downstream signaling molecules. Understanding the structure-function relationship of TLR3 through recombinant technology can provide insights into its role in various pathologies, including chronic inflammatory conditions and tumor immunology. As researchers explore the therapeutic potentials of TLR3, recombinant proteins are critical for elucidating mechanisms of action, developing TLR3-based therapies, and ultimately improving health outcomes in viral diseases and beyond.
