Analytical Data
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Gene name
COMP
- Application
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Alternative Names
MED; EDM1; EPD1; PSACH; THBS5; TSP-5; Pseudoachondroplasia,Epiphyseal Dysplasia 1,Multiple; Thrombospondin 5
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Species
Mouse
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Source
E. coli
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Tag
N-His
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Purity
Greater than 95% as determined by SDS-PAGE.
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Uniprot
Q9R0G6
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Expression Region
Gly463~Leu720
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Molecular Weight
70kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
COMP (cartilage oligomeric matrix protein) is a member of the thrombospondin family and plays a crucial role in cartilage development and homeostasis. Its significance is highlighted in studies related to cartilage integrity, joint diseases, and tissue engineering. The interest in COMP research has surged due to its potential as a biomarker for various musculoskeletal disorders, including osteoarthritis and rheumatoid arthritis. COMP's unique structure features multiple homologous domains, enabling interactions with other extracellular matrix components, which is key for maintaining the architecture and functionality of cartilage. Additionally, COMP has been implicated in modulating inflammatory responses and promoting cell survival in articular tissues. Recent advancements in recombinant protein production technologies have facilitated the generation of COMP for both in vitro and in vivo studies, enabling researchers to dissect its biological functions more thoroughly. Investigating COMP's role in pathological conditions could provide insights into novel therapeutic approaches aimed at preserving cartilage health and developing regenerative medicine strategies. The ongoing research into COMP's structure-function relationships and its interactions with cell signaling pathways continues to enhance our understanding of cartilage biology and its implications in joint diseases.
