Analytical Data
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Gene name
Neuritin
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简介
Neutritin is a key factor in neural development, significantly enhancing neurite growth and branching in hippocampal and cortical cells. In the AMPA receptor (AMPAR) complex, neuronal proteins help form the outer core and regulate the function and properties of these receptors. Neuritin Protein, Human (N-His) is the recombinant human-derived Neuritin protein, expressed by E. coli , with N-6*His labeled tag.
- Application
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Biological Activity
Measured in a cell proliferation assay using rat C6 cells. The ED50 this effect is 17.37 ng/ml, corresponding to a specific activity is 5.76×10^4 units/mg. Measured in a cell proliferation assay using rat C6 cells. The ED50 this effect is 17.37 ng/mL, corresponding to a specific activity is 5.76×104 units/mg.
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Alternative Names
Neuritin 1; Neuritin; NRN; Nrn1; NRN1_HUMAN; OTTHUMP00000015989; RP3 380B8.2 protein
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Species
Human
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Source
E. coli
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Tag
N-6*His
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Purity
Greater than 95% as determined by SDS-PAGE.
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Uniprot
Q9NPD7
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Expression Region
A28-N115
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Protein Length
Partial
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Molecular Weight
11 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Neuritin, a member of the extracellular matrix protein family, has garnered significant interest in neuroscience and regenerative medicine due to its crucial role in neuronal growth, synaptic plasticity, and neuroprotection. Initially identified in the context of developing neural tissues, Neuritin has been shown to promote neuronal survival and differentiation while enhancing synaptic connections. Research has demonstrated its involvement in modulating important signaling pathways, particularly those linked to neurotrophic factors. The therapeutic potential of Neuritin is being explored for various neurological disorders, such as Alzheimer's disease, depression, and spinal cord injuries, where neuronal repair and regeneration are critical. Recombinant Neuritin protein, produced through recombinant DNA technology, facilitates large-scale studies and applications in both basic research and clinical settings. Scientists are investigating its effects on neuronal behavior, signaling processes, and its capacity to facilitate recovery after injury. As ongoing studies continue to uncover the mechanisms underlying Neuritin’s function, its promise as a biomolecule for therapeutic intervention in neurodegenerative conditions and neuronal injuries becomes increasingly evident. The exploration of Neuritin's role in enhancing synaptic formation and plasticity positions it as a pivotal target in the quest for innovative treatments aimed at restoring neurological function.
