Analytical Data
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Gene name
PEA15
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简介
The PEA15 protein is a regulator of multiple cellular processes that blocks Ras-mediated integrin inhibition and modulates the ERK MAP kinase cascade. It inhibits RPS6KA3 activity by sequestering RPS6KA3 in the cytoplasm, regulating key cellular pathways. PEA15 Protein, Human is the recombinant human-derived PEA15 protein, expressed by E. coli , with tag free.
- Application
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Alternative Names
Astrocytic Phosphoprotein PEA-15; 15 kDa Phosphoprotein Enriched in Astrocytes; Phosphoprotein Enriched in Diabetes; PED; PEA15
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Species
Human
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Source
E. coli
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Tag
Tag Free
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q15121
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Expression Region
M1-A130
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Protein Length
Full Length
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Molecular Weight
12-16 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
PEA15 (Phosphoprotein Enriched in Astrocytes 15) is a multifunctional protein originally identified in astrocytes, playing key roles in various cellular processes, including apoptosis, proliferation, and signaling pathways. Its involvement in cancer has garnered considerable attention, as PEA15 has been shown to modulate apoptosis and cellular growth, particularly in neuronal and glial cells. Research indicates that PEA15 interacts with several proteins, such as ERK1/2, and exerts regulatory effects on the MAPK signaling pathway, which is vital for cell survival and differentiation. Dysregulation of PEA15 has been implicated in tumorigenesis, making it a potential biomarker and therapeutic target in various cancers, including gliomas and breast cancer. Furthermore, PEA15's role in neurodegenerative diseases, such as Alzheimer's and Parkinson's, highlights its importance in understanding both cancer and neurobiology. The study of PEA15 is crucial for elucidating its mechanisms in oncogenesis and neuroprotection, providing insights into potential therapeutic strategies for diseases associated with its dysregulation. As research progresses, the recombinant expression of PEA15 in model systems is expected to unveil its functional dynamics and potentials in therapeutic applications.
