Analytical Data
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基因名
Granzyme D/GZMD
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简介
Granzyme D (GZMD) serves as a crucial enzyme in the lysis of target cells during cell-mediated immune responses. Granzyme D/GZMD Protein, Mouse (HEK293, His) is the recombinant mouse-derived Granzyme D/GZMD protein, expressed by HEK293 , with C-6*His labeled tag.
- Application
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别名
rMuGranzyme D/GZMD, His; Granzyme D; Gzmd
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种属
Mouse
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表达系统
HEK293
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标签
C-6*His
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纯度
Greater than 95% as determined by SDS-PAGE.
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蛋白编号
P11033
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表达区间
I21-L252
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氨基酸序列
IIGGHVVKPHSRPYMAFVMSVDIKGNRIYCGGFLIQDDFVLTAAHCKNSSVQSSMTVTLGAHNITAKEETQQIIPVAKDIPHPDYNATIFYSDIMLLKLESKAKRTKAVRPLKLPRSNARVKPGDVCSVAGWGSRSINDTKASARLREVQLVIQEDEECKKRFRYYTETTEICAGDLKKIKTPFKGDSGGPLVCDNQAYGLFAYAKNGTISSGIFTKVVHFLPWISWNMKLL
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蛋白长度
Full Length of Mature Protein
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分子量
38-50 & 78-85 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Granzyme D (GZMD) is a member of the serine protease family, primarily produced by cytotoxic T lymphocytes and natural killer (NK) cells, playing a pivotal role in the immune response against tumor cells and virally infected cells. Unlike other granzymes, GZMD is unique in its ability to induce apoptosis in target cells through a caspase-independent pathway, which highlights its potential as a therapeutic target or diagnostic biomarker in cancer immunotherapy. The study of recombinant GZMD proteins has garnered attention due to their importance in enhancing our understanding of immune mechanisms and developing novel treatment strategies. Research indicates that GZMD has the potential to modulate inflammatory responses, and its dysregulation has been implicated in various diseases. Additionally, recombinant forms of GZMD can be utilized in functional studies to dissect its role in immune regulation and cell signaling pathways. Given its distinctive modes of action and implications in health and disease, GZMD continues to be a subject of extensive research, aiming to harness its properties for innovative therapeutic approaches. Understanding the structure, function, and mechanisms of GZMD through recombinant protein studies is critical for the development of targeted immunotherapies and for advancing our knowledge of immune evasion by tumors or pathogens.
