Analytical Data
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Gene name
Annexin A13/ANXA13
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简介
Annexin A13/ANXA13 protein has a high affinity for folic acid and can bind to reduced folic acid derivatives to promote the transport of 5-methyltetrahydrofolate and folic acid analogs into cells. After endocytosis, the FOLR1 protein undergoes conformational changes when exposed to slightly acidic pH, resulting in a significant reduction in its affinity for folate and subsequent release. Annexin A13/ANXA13 Protein, Dog (P.pastoris, His) is the recombinant dog-derived Annexin A13/ANXA13 protein, expressed by P. pastoris , with N-His labeled tag.
- Application
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Alternative Names
ANXA13; ANX13Annexin A13; Annexin XIII; Annexin-13; Intestine-specific annexin; ISA
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Species
Dog
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Source
P. pastoris
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q29471-1
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Expression Region
G2-H316
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AA Sequence
GNRHAKAKSHHGFDVDHDAKKLNKACKGMGTDEAAIIEILSSRTSDERQQIKQKYKATYGKDLEEVFKSDLSGNFEKTALALLDRPSEYDARQLQKAMKGLGTDEAVLIEILCTRTNKEIMAIKEAYQRLFDRSLESDVKADTSGNLKAILVSLLQANRDEGDDVDKDLAGQDAKDLYDAGDGRWGTDELAFNEVLAKRSHKQLRATFQAYQILIDKDIEEAIEAETSGDLQKAYLTLVRCARDQEGYFADRLYKSMKGTGTDEETLIHIIVTRAEVDLQGIKAKFQEKYQKSLSDMVRSDTSGDFQKLLVALLH
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Protein Length
Full Length of Isoform-1 Mature Protein
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
Annexin A13 (ANXA13) is a member of the annexin family of proteins that exhibit calcium-dependent phospholipid binding, playing crucial roles in various cellular processes including membrane trafficking, cell signaling, and apoptosis. Initially identified in the human brain, ANXA13 has garnered interest due to its potential involvement in pathophysiological conditions such as cancer progression and neurodegenerative diseases. Unlike other annexins, ANXA13 has a unique structure and is characterized by a longer N-terminal domain, which may confer distinct functional properties. Recent studies suggest that ANXA13 might act as an important regulator of endocytosis and exocytosis, impacting cellular repair mechanisms and inflammatory responses. Given its diverse functions and implications in disease, the development of recombinant ANXA13 protein offers a valuable tool for elucidating its molecular mechanisms and interactions in cellular contexts. Research involving this recombinant protein can facilitate a deeper understanding of its role in physiological and pathological processes, potentially leading to new therapeutic strategies targeting ANXA13-related pathways.
