Analytical Data
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Gene name
Granzyme H/GZMH
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简介
The Granzyme H/GZMH protein, encoded by this gene, belongs to the peptidase S1 family. It is expressed in NK cells and plays a role in the cytotoxic arm of the innate immune response. It induces target cell death and cleaves substrates in infected cells. It is located on chromosome 14 and is broadly expressed, including in the spleen, bone marrow, and 21 other tissues. Granzyme H/GZMH Protein, Human (HEK293, His) is the recombinant human-derived Granzyme H/GZMH, expressed by HEK293, with C-His labeled tag. The total length of Granzyme H/GZMH Protein, Human (HEK293, His) is 228 a.a..
- Application
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Alternative Names
Granzyme H; CCP-X; CTSGL2; CSP-C; GZMH; CGL2
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Species
Human
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Source
HEK293
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Tag
C-6*His
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Purity
Greater than 95% as determined by SDS-PAGE.
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Uniprot
NP_219491.1
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Expression Region
E19-L246
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Protein Length
Full Length of Mature Protein
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Molecular Weight
35-40 kDa band in SDS-PAGE under reducing conditions.
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Granzyme H (GZMH) is a serine protease that belongs to the granzyme family, primarily expressed in cytotoxic T lymphocytes and natural killer (NK) cells. It plays a significant role in the immune response by inducing apoptosis in target cells, particularly virally infected or tumor cells. Research has highlighted GZMH's unique substrate specificity and its distinct role compared to other granzymes, making it a focus of immunological studies, especially in the context of cancer immunotherapy and viral infections. The recombinant production of GZMH has enabled researchers to investigate its biochemical properties, cellular functions, and interactions with various substrates. Studying GZMH can provide critical insights into the mechanisms of immune evasion used by tumors and pathogens, offering potential therapeutic targets for enhancing immune responses in cancer treatment and improving antiviral strategies. The ongoing investigation of GZMH in both basic and applied research aims to elucidate its role in the immune system and explore its potential as a biomarker or therapeutic agent.
