Analytical Data
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Gene name
OSMR
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简介
The OSMR beta Protein, in partnership with IL31RA, constitutes the IL31 receptor, binding IL31 to activate STAT3, and potentially STAT1 and STAT5.OSMR beta also transduces OSM-specific signaling.It forms a heterodimer with IL6ST, creating the type II OSM receptor, and another heterodimer with IL31RA for the IL31 receptor.OSMR beta Protein, Mouse (HEK293, His) is the recombinant mouse-derived OSMR beta protein, expressed by HEK293 , with C-His labeled tag.
- Application
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Biological Activity
Measured by its binding ability in a functional ELISA. When Recombinant Mouse OSM R beta is immobilized at 0.5 µg/mL and Recombinant Mouse gp130 at 0.5 µg/mL (100 µL/well) can bind Recombinant Mouse OSM. The ED50 for this effect is 0.9183 ng/mL. Measured by its binding ability in a functional ELISA. When Recombinant Mouse OSM R beta is immobilized at 0.5 µg/mL and Recombinant Mouse gp130 at 0.5 µg/mL (100 µL/well) can bind Recombinant Mouse OSM. The ED50 for this effect is 0.9183 ng/mL.
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Alternative Names
IL-31R subunit beta; IL-31R-beta; IL-31RB; OSMR beta; OSMR; OSMRB; OSMRBMGC150626; PLCA1 ; IL-31R subunit β; IL-31R-β; OSMR β
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Species
Mouse
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Source
HEK293
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Tag
C-8*His;C-His
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Purity
> 90% as determined by SDS-PAGE.
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Uniprot
O70458
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Expression Region
E24-M737
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Protein Length
Partial
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Molecular Weight
115-140 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
OSMR (Oncostatin M receptor) is a member of the interleukin-6 receptor family, playing a crucial role in various physiological processes, including inflammation, hematopoiesis, and development. Research into OSMR has gained momentum due to its involvement in several pathological conditions, such as cancer, autoimmune diseases, and infections. The receptor mediates the effects of oncostatin M, a cytokine that influences cell proliferation, differentiation, and survival. Moreover, OSMR's signaling pathways, particularly those involving Janus kinases (JAKs) and signal transducers and activators of transcription (STATs), are central to understanding the receptor's function in both normal and disease states. Recent studies have highlighted the potential for OSMR as a therapeutic target, as its modulation could provide novel approaches for treating diseases characterized by dysregulated inflammatory responses. Therefore, the development of recombinant OSMR proteins is essential for further elucidating its biological functions, exploring its role in cellular signaling, and assessing its therapeutic potential. The ongoing research into OSMR and its recombinant forms not only aims to expand our understanding of immune regulation and cellular communication but also seeks to pave the way for innovative treatments that harness the biology of this receptor in disease management.
