Analytical Data
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基因名
CREG1/CREG
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简介
CREG1/CREG is a potential regulator in transcriptional control that antagonizes adenovirus E1A-induced activation, emphasizing its role in regulating cell growth and differentiation. The glycosylation-dependent interaction with IGF2R highlights the multifaceted nature of CREG1/CREG in the molecular mechanisms governing transcriptional control. CREG1/CREG Protein, Mouse (HEK293, His) is the recombinant mouse-derived CREG1/CREG protein, expressed by HEK293 , with C-6*His labeled tag.
- Application
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生物活性
Measured by its binding ability in a functional ELISA. Immobilized IGF-II R at 2 μg/mL (100 μL/well) can bind Biotinylated CREG. The ED50 for this effect is 17.01 ng/mL. Measured by its binding ability in a functional ELISA. Immobilized IGF-II R at 2 μg/mL (100 μL/well) can bind Biotinylated CREG. The ED50 for this effect is 17.01 ng/mL.
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别名
rMuProtein CREG1/CREG, His; CREG1; cellular repressor of E1A-stimulated genes; cellular repressor of E1A-stimulated genes 1CREG; protein CREG1
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种属
Mouse
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表达系统
HEK293
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标签
C-6*His
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纯度
Greater than 95% as determined by SDS-PAGE.
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蛋白编号
O88668
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表达区间
R32-Q220
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氨基酸序列
RGGRDHGDWDVDRRLPPLPPREDGPRVARFVTHVSDWGSLATISTIKEVRGWPFADIISISDGPPGEGTGEPYMYLSPLQQAVSDLQENPEATLTMSLAQTVYCRNHGFDPQSPLCVHIMMSGTVTKVNKTEEDYARDSLFVRHPEMKHWPSSHNWFFAKLKISRIWVLDYFGGPKVVTPEEYFNVTLQ
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蛋白长度
Full Length of Mature Protein
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分子量
26-34 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CREG1, also known as CREG (Cellular Regulator of EGF), is a secreted protein that has garnered attention due to its role in various physiological and pathological processes. Initially identified for its involvement in cell proliferation and differentiation, CREG1 has since been implicated in tissue repair, inflammation, and cancer progression. Its expression is regulated by several growth factors and cytokines, suggesting its role as a modulator in cellular responses. The protein interacts with key pathways such as the EGF receptor signaling, influencing cellular behaviors critical for development and response to injury. Recent studies have highlighted the potential of CREG1 as a therapeutic target due to its dual role in promoting tissue regeneration while also participating in tumorigenesis. Moreover, research into the recombinant production of CREG1 aims to harness its biological functions for clinical applications, such as enhancing wound healing or developing anti-cancer therapies. As understanding of CREG1’s molecular mechanisms deepens, it holds promise for advancing regenerative medicine and oncology, making it a significant focus in current biomedical research.
