Analytical Data
-
基因名
RAC2
-
简介
The RAC2 protein is a plasma membrane-associated small GTPase that dynamically regulates cellular responses by cycling between an active GTP-bound state and an inactive GDP-bound state. In its active state, RAC2 regulates secretory function, phagocytosis, and epithelial cell polarization. RAC2 Protein, Human (His) is the recombinant human-derived RAC2 protein, expressed by E. coli , with N-His labeled tag.
- Application
-
别名
Ras-related C3 botulinum toxin substrate 2; GX; Small G protein; p21-Rac2
-
种属
Human
-
表达系统
E. coli
-
标签
N-His
-
纯度
Greater than 90% as determined by SDS-PAGE.
-
蛋白编号
P15153
-
表达区间
M1-C189
-
氨基酸序列
MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDSKPVNLGLWDTAGQEDYDRLRPLSYPQTDVFLICFSLVSPASYENVRAKWFPEVRHHCPSTPIILVGTKLDLRDDKDTIEKLKEKKLAPITYPQGLALAKEIDSVKYLECSALTQRGLKTVFDEAIRAVLCPQPTRQQKRAC
-
蛋白长度
Partial
-
分子量
25 kDa
-
内毒素
< 1.0 EU per μg protein as determined by the LAL method.
-
性状
Freeze-dried powder
-
缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
-
稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
RAC2, a member of the Rho family of GTPases, plays a pivotal role in regulating various cellular functions, including actin cytoskeleton organization, cell migration, and immune responses. Its unique expression pattern, predominantly in hematopoietic cells, underscores its significance in immune system functioning. Research has highlighted that mutations or dysregulation of RAC2 can lead to immunodeficiencies and contribute to the development of certain cancers, making it an attractive target for therapeutic intervention. The study of RAC2 recombinant proteins is crucial for elucidating its molecular mechanisms and interactions within signaling pathways. By generating and characterizing RAC2 recombinant proteins, researchers aim to better understand its role in cellular processes and identify potential therapeutic targets for diseases associated with its dysregulation. This investigative work not only enhances our comprehension of RAC2's functional capabilities but also lays the groundwork for novel approaches in treating immune-related disorders and malignancies.
