Analytical Data
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基因名
H2BC11
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简介
The H2BC11 protein functions as a core component of nucleosomes, the fundamental units in chromatin structure that wrap and compact DNA, regulating its accessibility to cellular processes that require DNA as a template. Histones, including H2BC11, play central roles in transcriptional regulation, DNA repair, DNA replication, and chromosome stability. H2BC11 Protein, Human is the recombinant human-derived H2BC11 protein, expressed by E. coli , with tag free.
- Application
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别名
H2BC11; Histone H2B type 1-J
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种属
Human
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表达系统
E. coli
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标签
Tag Free
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P06899
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表达区间
P2-K126
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蛋白长度
Full Length of Mature Protein
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分子量
13.8 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
H2BC11 is a histone H2B variant that has garnered increased attention in the field of epigenetics and chromatin biology due to its potential roles in gene regulation and chromatin dynamics. Histone variants are known to influence the structure and function of chromatin, thereby affecting transcriptional activity and cellular processes such as differentiation and development. H2BC11, specifically, has been implicated in modulating the epigenetic landscape through mechanisms that may involve post-translational modifications and interactions with other chromatin-associated proteins. Research on H2BC11 aims to elucidate its specific functional roles in various biological contexts, including its contribution to maintaining genomic stability and its potential implications in diseases such as cancer. The recombinant production of H2BC11 facilitates detailed biochemical studies that can uncover its mechanisms of action, binding partners, and the impact of its modifications on chromatin structure and function. Understanding the intricate roles of H2BC11 can provide valuable insights into broader epigenetic regulation and may pave the way for novel therapeutic strategies targeting chromatin-related disorders. Thus, H2BC11 serves as an intriguing subject of investigation within the broader narrative of histone research and its implications for gene expression and cellular identity.
