Analytical Data
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基因名
Lactoferrin/LTF
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简介
Lactoferrin (LTF) is a major iron-binding protein in exocrine fluid and exhibits multiple antibacterial effects by chelating iron and disrupting bacterial membranes. It prevents biofilm formation, affects bone metabolism, and affects adenovirus and papillomavirus infections. Lactoferrin/LTF Protein, Human (691a.a, HEK293, His) is the recombinant human-derived Lactoferrin/LTF protein, expressed by HEK293 , with C-6*His labeled tag.
- Application
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别名
rHuLactotransferrin/LTF, His; Lactotransferrin; Lactoferrin; Talalactoferrin; Kaliocin-1; Lactoferroxin-A; Lactoferroxin-B; Lactoferroxin-C; LTF; LF
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种属
Human
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表达系统
HEK293
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标签
C-6*His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
AAH15822.1
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表达区间
G20-K711
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氨基酸序列
GSRRRSVQWCAVSQPEATKCFQWQRNMRKVRGPPVSCIKRDSPIQCIQAIAENRADAVTLDGGFIYEAGLAPYKLRPVAAEVYGTERQPRTHYYAVAVVKKGGSFQLNELQGLKSCHTGLRRTAGWNVPIGTLRPFLNWTGPPEPIEAAVARFFSASCVPGADKGQFPNLCRLCAGTGENKCAFSSQEPYFSYSGAFKCLRDGAGDVAFIRESTVFEDLSDEAERDEYELLCPDNTRKPVDKFKDCHLARVPSHAVVARSVNGKEDAIWNLLRQAQEKFGKDKSPKFQLFGSPSGQKDLLFKDSAIGFSRVPPRIDSGLYLGSGYFTAIQNLRKSEEEVAARRARVVWCAVGEQELRKCNQWSGLSEGSVTCSSASTTEDCIALVLKGEADAMSLDGGYVYTAGKCGLVPVLAENYKSQQSSDPDPNCVDRPVEGYLTVAVVRRSDTSLTWNSVKGKKSCHTAVDRTAGWNIPMGLLFNQTGSCKFDEYFSQSCAPGSDPRSNLCALCIGDEQGENKCEPNSNERYYGYTGAFRCLAENAGDVAFVKDVTVLQNTDGNNNEAWAKDLKLADFALLCLDGKRKPVTEARSCHLAMAPNHAVVSRMDKVERLKQVLLHQQAKFGRNGSDCPDKFCLFQSETKNLLFNDNTECLARLHGKTTYEKYLGPQYVAGITNLKKCSTSPLLEACEFLRK
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蛋白长度
Partial
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分子量
83 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Lactoferrin (LTF) is an iron-binding glycoprotein primarily found in milk and other secretions, known for its multifunctional roles in the immune system, iron metabolism, and antimicrobial activity. Research into recombinant lactoferrin has gained prominence due to its potential therapeutic applications, particularly in enhancing immune responses and acting as a natural antibacterial agent. The development of recombinant LTF involves the use of genetic engineering techniques to produce this protein in various host systems, allowing for better yields and more accessible production compared to traditional extraction methods from natural sources. Investigations into its structure-function relationships aim to elucidate the mechanisms by which LTF exerts its biological effects, while studies exploring its use in dietary supplements and functional foods highlight its potential benefits in promoting gut health and overall well-being. The growing interest in the health benefits associated with lactoferrin has positioned it as a key target for biotechnological advancements, fueling research initiatives that seek to harness its properties for clinical applications in immunology and nutrition. Moreover, the rising prevalence of antibiotic resistance has further underscored the need for alternative antimicrobial agents like lactoferrin, making its study increasingly relevant in the context of public health.
