Analytical Data
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Gene name
TGFBR1/ALK-5
- Application
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Alternative Names
ACVRLK4; AAT5; ALK5; SKR4; TGFR-1; Activin A Receptor Type II-Like Kinase 53kDa; Activin receptor-like kinase 5; Serine/threonine-protein kinase receptor R4
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 97% as determined by SDS-PAGE.
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Uniprot
P36897
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Expression Region
Glu162~Ala403
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Protein Length
Partial
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Molecular Weight
33kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
TGFBR1, also known as TGF-β receptor type I, is a key component of the TGF-β signaling pathway, which plays a crucial role in regulating various physiological processes, including cell growth, differentiation, and apoptosis. Abnormalities in this pathway are implicated in numerous diseases, including cancer, fibrosis, and autoimmune disorders. ALK-5, another designation for TGFBR1, serves as a receptor that transduces the signals initiated by TGF-β ligands. Research into TGFBR1/ALK-5 recombinant proteins has gained significant attention due to their potential therapeutic applications. By creating recombinant forms of this receptor, scientists aim to study its functional properties and signaling mechanisms in greater detail. These studies can help elucidate how TGF-β signaling contributes to disease pathogenesis and may identify novel targets for intervention. Moreover, understanding the structure and dynamics of TGFBR1 can facilitate the design of drugs that specifically modulate its activity, offering hope for tailored treatments in related diseases. Thus, TGFBR1/ALK-5 recombinant proteins represent a valuable tool in biomedical research, advancing our knowledge of TGF-β signaling and its impact on human health.
