Analytical Data
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基因名
CMBL
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简介
The CMBL protein is a cysteine hydrolase that converts olmesartan medoxomil to its active form olmesartan, an angiotensin receptor blocker. It may also activate beta-lactam antibiotics such as faropenem etexil and renamcillin. CMBL Protein, Human (His) is the recombinant human-derived CMBL protein, expressed by E. coli , with N-His labeled tag.
- Application
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生物活性
1.The enzyme activity of this recombinant protein is testing in progress, we cannot offer a guarantee yet. 2.Measured by its ability to inhibit the proliferation of human colon cancer cells. The ED50 for this effect is 38.07 ng/mL. Corresponding to a specific activity is 2.627×104 Unit/mg Measured by its ability to inhibit the proliferation of human colon cancer cells. The ED50 for this effect is 38.07 ng/mL. Corresponding to a specific activity is 2.627×104 Unit/mg.
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别名
Carboxymethylenebutenolidase homolog; CMBL
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种属
Human
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 95% as determined by SDS-PAGE.
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蛋白编号
Q96DG6
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表达区间
M1-M245
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氨基酸序列
MANEAYPCPCDIGHRLEYGGLGREVQVEHIKAYVTKSPVDAGKAVIVIQDIFGWQLPNTRYIADMISGNGYTTIVPDFFVGQEPWDPSGDWSIFPEWLKTRNAQKIDREISAILKYLKQQCHAQKIGIVGFCWGGTAVHHLMMKYSEFRAGVSVYGIVKDSEDIYNLKNPTLFIFAENDVVIPLKDVSLLTQKLKEHCKVEYQIKTFSGQTHGFVHRKREDCSPADKPYIDEARRNLIEWLNKYM
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蛋白长度
Full Length
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分子量
28 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CMBL (Cysteine-rich secretory protein, LCCL domain-containing 2) is a novel protein implicated in various biological processes, including inflammation, immune response, and cancer progression. Its reconstitution in vitro has attracted significant attention due to its potential therapeutic applications. Studies have shown that CMBL plays a crucial role in modulating the immune system's response to pathogens and tumors, suggesting it could serve as a biomarker for disease monitoring or a target for novel drug development. Additionally, understanding the structural and functional properties of CMBL, including its interactions with various cellular components, is essential for deciphering its role in disease mechanisms. Researchers are focusing on the recombinant expression of CMBL to create a stable source of this protein for functional assays, high-throughput screening, and structural analysis. Investigating the pathways influenced by CMBL, as well as its regulatory mechanisms, may unveil new insights into how this protein can be leveraged in therapeutic contexts. The growing body of research surrounding CMBL highlights its significance in advancing our understanding of complex biological systems and its potential utility in clinical applications.
