Analytical Data
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基因名
APBA3
- Application
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别名
X11L2; Mint3; APB-A3; Adapter protein X11gamma; Neuron-specific X11L2 protein; Neuronal Munc18-1-interacting protein 3
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种属
Mouse
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 95% as determined by SDS-PAGE.
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蛋白编号
O88888
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表达区间
Val261~Leu506
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分子量
33kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
APBA3, or APBB3 (Amyloid Beta A4 Precursor Protein-Binding, Family A, Member 3), is a member of the APBA family, which is implicated in various cellular processes, including protein sorting and endocytosis. Research on APBA3 has gained significant attention due to its potential role in neurodegenerative diseases, particularly Alzheimer's disease. APBA3 interacts with the amyloid precursor protein (APP) and is believed to influence the processing and aggregation of amyloid-beta peptides, key players in the pathological hallmark of Alzheimer's. Additionally, APBA3 is involved in synaptic function and neuronal signaling, suggesting it may have implications beyond simply amyloid pathology. The study of APBA3 recombinantly expressed proteins provides insights into its structural, functional, and interaction properties, which could illuminate its role in cellular mechanisms and disease states. Understanding APBA3 could pave the way for targeted therapies that mitigate the progression of Alzheimer’s and related conditions, making it a focus of pharmaceutical research and a potential biomarker for disease progression. As characterization of its function and mechanisms continues, APBA3 presents an appealing target for therapeutic intervention aimed at alleviating cognitive decline associated with neurodegenerative disorders.
