Analytical Data
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Gene name
BMP-2
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简介
BMP-2 protein is an important member of the TGF-β superfamily and is critical in cardiogenesis, neurogenesis, and osteogenesis, inducing cartilage and bone formation. It initiates canonical BMP signaling by binding to BMPR1A and BMPR2, triggering BMPR2 phosphorylation and SMAD1/5/8 activation for gene transcription regulation. BMP-2 Protein, Human/Mouse/Rat (P. pastoris, His) is the recombinant human-derived BMP-2 protein, expressed by P. pastoris , with N-6*His labeled tag.
- Application
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Alternative Names
Bone morphogenetic protein 2A; BMP-2A; BDA2; SSFSC; SSFSC1
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Species
Human; Mouse; Rat
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Source
P. pastoris
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Tag
N-6*His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P12643
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Expression Region
Q283-R396
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Protein Length
Full Length of Mature Protein
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Molecular Weight
17 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
BMP-2 (Bone Morphogenetic Protein-2) is a member of the BMP family, which plays a crucial role in bone and cartilage formation, as well as tissue regeneration. Research into BMP-2 recombinant protein has gained significant attention due to its potential applications in regenerative medicine and orthopedic surgery. BMP-2 promotes the differentiation of mesenchymal stem cells into osteoblasts, enhancing bone healing and regeneration processes. Studies have demonstrated its efficacy in promoting bone formation, making it a beneficial agent for treating bone defects and fractures. Additionally, BMP-2 has been utilized in various biomaterials for bone grafting, improving their osteoinductive properties. However, concerns regarding the controlled delivery and dosage, as well as potential side effects such as inappropriate bone growth, highlight the need for further research. Understanding the biological mechanisms underlying BMP-2 activity and optimizing its recombinant production are critical for harnessing its therapeutic benefits while minimizing risks. Thus, ongoing studies focus on enhancing the safety and efficacy of BMP-2 applications, exploring its use in conjunction with advanced biomaterials and tissue engineering strategies to improve patient outcomes in skeletal repair and regeneration.
