Analytical Data
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Gene name
TMED9
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简介
TMED9 is a key player in vesicle protein trafficking and plays an important role in the early secretory pathway, particularly in COPI vesicle-mediated retrograde transport. It promotes the recruitment of coat isoforms to the membrane, enhances ARFGAP2 activity, and ensures the specific retention of p24 complexes in cis-Golgi membranes, specifically affecting TMED2 and TMED10 localization. TMED9 Protein, Human (HEK293, Fc) is the recombinant human-derived TMED9 protein, expressed by HEK293 , with C-mFc labeled tag.
- Application
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Alternative Names
Transmembrane emp24 domain-containing protein 9; GMP25; p24alpha2; p25; GP25L2
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Species
Human
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Source
HEK293
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Tag
C-mFc
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9BVK6
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Expression Region
M1-R202
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Protein Length
Partial
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Molecular Weight
45.8 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TMED9, a member of the transmembrane emp24 domain (TMED) protein family, has garnered significant interest in recent years due to its critical role in protein trafficking and secretion within the cell. This protein primarily functions in the endoplasmic reticulum (ER) and Golgi apparatus, mediating the transport of newly synthesized proteins to their final destinations. Dysregulation of TMED9 has been implicated in various diseases, including cancer and neurodegenerative disorders, highlighting its potential as a therapeutic target. Studies suggest that TMED9 interacts with various cargo proteins, influencing their maturation and export processes, which further underlines its importance in maintaining cellular homeostasis. Additionally, the use of recombinant TMED9 protein in biological assays has facilitated the exploration of its structural and functional properties, providing insights into its mechanisms of action. Understanding the intricate details of TMED9's function could lead to novel approaches in treating diseases where protein trafficking is disrupted, making it a focal point for ongoing research in cell biology and biomedicine.
