Analytical Data
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Gene name
TSC22/TSC22D1
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简介
TSC22D1 protein, possessing RNA polymerase II binding activity, regulates apoptotic and cell proliferation processes. It is found in the cytoplasm and nucleus and expressed in multiple structures like the alimentary system and central nervous system. With ubiquitous expression observed, TSC22D1 likely regulates diverse cellular processes across tissues. TSC22/TSC22D1 Protein, Mouse (His) is the recombinant mouse-derived TSC22/TSC22D1 protein, expressed by E. coli , with N-His labeled tag.
- Application
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Alternative Names
TSC22 domain family protein 1; Cerebral protein 2; KIAA1994; TGFB1I4
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Species
Mouse
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
NP_033392
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Expression Region
M1-A143
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Protein Length
Full Length
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The TSC22 (TSC22 Domain Family Member 1) gene, particularly its isoform TSC22D1, plays a significant role in various biological processes, including immune response, apoptosis, and cell differentiation. TSC22D1 is known to act as a transcriptional regulator, and it has been implicated in the modulation of inflammatory responses and the regulation of cell growth. Research has shown that TSC22D1 can influence numerous signaling pathways, making it a potential biomarker for certain diseases and therapeutic targets. Its expression is often associated with various conditions, including autoimmune diseases and cancers, highlighting its importance in pathological and physiological states. The study of recombinant TSC22/TSC22D1 proteins allows for a deeper understanding of their functional roles in cellular processes and disease mechanisms. By producing these proteins in a laboratory setting, researchers can investigate their structure, interactions with other molecules, and potential as drug targets, thus providing insights into novel therapeutic strategies for conditions linked to their dysregulation. As such, TSC22D1 represents a promising avenue for research in molecular biology and biomedical applications, warranting further exploration of its functions and implications in human health.
