Analytical Data
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Gene name
Mucin-15/MUC15
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简介
MUC15 is a membrane-bound mucin. The human MUC15 protein contains an extracelluar domain, a small transmembrane domain, and a highly conserved cytoplasmic tail. MUC15 overexpression suppresses trophoblast-like cell invasion[1][2]. Mucin-15/MUC15 Protein, Cynomolgus (HEK293, Fc) is the recombinant cynomolgus-derived Mucin-15/MUC15 protein, expressed by HEK293 , with C-hFc labeled tag.
- Application
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Alternative Names
Mucin 1; MUC1; CD227; EMA; H23AG; KL-6; MAM6; MUC-1; SEC; MUC-1; X; MUC1; ZD; PEM; PEMT; PUM; CA15-3; Episialin
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Species
Cynomolgus
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Source
HEK293
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Tag
C-hFc
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
XP_005541632.1
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Expression Region
L254-G373
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Molecular Weight
48 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Mucin-15 (MUC15) is a member of the mucin family of glycoproteins, which play critical roles in cell signaling, adhesion, and protection of epithelial surfaces. Its expression is predominant in various tissues, particularly in the placenta and certain types of epithelial cells, suggesting potential roles in developmental processes and tumor biology. Research indicates that MUC15 may be involved in modulating immune responses, with implications for its function in both normal physiology and disease states, including cancer. The interest in MUC15 as a biomarker has grown, driven by its distinct expression profiles in malignancies, making it a potential target for diagnostic and therapeutic strategies. To further understand MUC15’s biological roles, researchers have focused on the production of recombinant MUC15 protein. This recombinant protein can facilitate studies related to its structure-function relationships, interactions with other molecules, and functional assays, ultimately providing insights into its mechanisms of action in health and disease. Additionally, the availability of MUC15 in recombinant form allows for comprehensive investigations into its potential as a therapeutic target, particularly in cancer immunotherapy. Understanding the precise mechanisms by which MUC15 contributes to pathological processes could pave the way for novel interventions, enhancing clinical outcomes for patients with diseases characterized by dysregulated mucin expression. Overall, the study of MUC15 and its recombinant protein form embodies a promising area of research with significant implications for translational medicine and improved diagnostic strategies.
