Analytical Data
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Gene name
SLC17A3
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简介
SLC17A3 is a voltage-driven organic anion transporter that plays a critical role in the renal proximal tubule. It actively promotes urate secretion and is essential for the elimination of the end products of purine metabolism. SLC17A3 Protein, Human (sf9, His, MBP, FLAG) is the recombinant human-derived SLC17A3 protein, expressed by sf9 insect cells , with N-MBP, C-Flag, N-8*His labeled tag.
- Application
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Alternative Names
SLC17A3; Sodium-dependent phosphate transport protein 4; Na(+)/PI cotransporter 4; Sodium/phosphate cotransporter 4; Solute carrier family 17 member 3
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Species
Human
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Source
Baculovirus
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Tag
N-MBP;C-Flag;N-8*His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O00476
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Expression Region
A2-L420
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Protein Length
Full Length
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
SLC17A3, also known as the sodium-dependent inorganic phosphate transporter 3, is a member of the solute carrier family that plays a crucial role in phosphate homeostasis and cellular transport processes. Its primary function involves the uptake of inorganic phosphate from extracellular space, which is vital for various physiological processes, including bone mineralization, energy metabolism, and cellular signaling. Dysregulation of SLC17A3 has been associated with various pathological conditions, including chronic kidney disease and osteomalacia, highlighting its importance in both health and disease. Research into the recombinant protein of SLC17A3 aims to elucidate its structural and functional characteristics, facilitating better understanding of its transport mechanisms and potential regulatory pathways. By producing a recombinant version of this protein, scientists can conduct detailed functional assays, evaluate its interaction with other cellular components, and explore the impact of different substrates and inhibitors. Additionally, these studies can provide insights into therapeutic targets for managing disorders linked to phosphate imbalance. Consequently, SLC17A3 recombinant protein research holds significant promise in advancing our knowledge of phosphate transport processes and developing novel interventions for related diseases.
