Analytical Data
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Gene name
NPDC-1
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简介
NPDC-1 protein critically hinders oncogenic transformation in neural and non-neural cells, suppressing neural cell proliferation. Its multifaceted impact extends to transcriptional regulation, emphasizing its role as a regulator with implications for mitigating oncogenic processes and modulating cellular proliferation in diverse cell systems. NPDC-1 Protein, Human (HEK293, His) is the recombinant human-derived NPDC-1 protein, expressed by HEK293 , with C-6*His labeled tag.
- Application
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Alternative Names
Neural proliferation differentiation and control protein 1; NPDC-1; NPDC1; RP11-229P13.1; CAB; CAB-1; CAB1
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Species
Human
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Source
HEK293
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Tag
C-6*His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9NQX5
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Expression Region
G35-D181
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Protein Length
Partial
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Molecular Weight
28-35 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
NPDC-1 (Neuron-Precursor-Cell-Death) is a protein that has gained significant attention in recent years due to its potential role in neurodevelopment and neurodegenerative diseases. Originally identified in neuronal precursor cells, NPDC-1 is thought to be involved in regulating cell survival and differentiation during the early stages of brain development. Research indicates that alterations in NPDC-1 expression may be linked to conditions such as Alzheimer's disease and other neurodegenerative disorders, suggesting that it plays a critical role in neuronal health. Recent studies have focused on the structural and functional properties of NPDC-1, exploring its interactions with various signaling pathways and molecular partners. Understanding NPDC-1's mechanisms could provide valuable insights into the underlying biological processes that lead to neuronal loss and impaired function. As researchers develop recombinant NPDC-1 proteins for experimental use, they aim to clarify its biological roles and therapeutic potential, paving the way for innovative strategies to combat neurodegeneration. The investigation of NPDC-1 not only enhances our understanding of cellular processes in the nervous system but also underscores the importance of molecular targets in the development of future treatments for neurological disorders.
