Analytical Data
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Gene name
GATA2
- Application
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Alternative Names
Endothelial transcription factor GATA-2; GATA-binding protein 2; GATA2; Homo sapiens; Human; Activator; DNA-binding
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Species
Human
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Source
E. coli
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Tag
Strep;His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P23769-1
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Expression Region
G292-S401
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Protein Length
Partial
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
GATA2 is a transcription factor that plays a crucial role in hematopoiesis, immune response, and organ development. Mutations in the GATA2 gene have been associated with various hematological disorders and immunodeficiencies, highlighting its significance in maintaining proper cellular function and differentiation. Research on GATA2 has gained importance due to its involvement in diseases such as monocytopenia, myelodysplastic syndromes, and certain cancers. The exploration of GATA2 as a recombinant protein has been driven by the need to understand its functional properties and regulatory mechanisms at a molecular level. By producing GATA2 as a recombinant protein, researchers can investigate its interaction with DNA and other transcriptional co-factors, elucidate its role in gene expression regulation, and identify potential therapeutic targets. Additionally, recombinant GATA2 can be utilized in high-throughput screening assays to discover small molecules or peptides that may modulate its activity, contributing to potential treatment strategies for GATA2-related disorders. The characterization of GATA2-recombinant protein has significant implications in both clinical and research settings, offering insights into the fundamental processes of cell biology and the development of innovative approaches for managing GATA2-linked diseases.
