Analytical Data
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基因名
CaMKII alpha/CAMK2A
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简介
CaMKII α/CAMK2A protein functions autonomously upon Ca(2+)/calmodulin binding and autophosphorylation. CaMKII alpha/CAMK2A Protein, Human (sf9, GST) is the recombinant human-derived CaMKII alpha/CAMK2A protein, expressed by Sf9 insect cells , with N-GST labeled tag.
- Application
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别名
Calcium/calmodulin-dependent protein kinase type II subunit alpha; CAMKA
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种属
Human
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表达系统
Baculovirus
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标签
N-GST
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纯度
Greater than 95% as determined by SDS-PAGE.
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蛋白编号
Q9UQM7-1
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表达区间
M1-H478
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蛋白长度
Full Length of Isoform-1
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分子量
80 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CaMKII alpha, or Ca2+/calmodulin-dependent protein kinase II alpha (CAMK2A), is a serine/threonine protein kinase that plays a crucial role in various cellular processes, particularly in the nervous system. It is involved in calcium signaling pathways, learning, memory formation, and synaptic plasticity, making it a key player in neuronal function and development. Research into CAMK2A has revealed its significance in various neurological disorders, including Alzheimer's disease, schizophrenia, and autism spectrum disorders. Given its central role in synaptic transmission and plasticity, CAMK2A has gained attention as a potential therapeutic target. The study of recombinant CAMK2A proteins allows scientists to explore its enzymatic activity, regulatory mechanisms, and interaction with other cellular partners in controlled experimental settings. Understanding the structure and function of CAMK2A is essential for developing innovative strategies to modulate its activity in disease treatment, making it a focal point of contemporary neurobiology research.
