Analytical Data
-
Gene name
ACVRL1/ALK1
-
简介
ALK-1, also known as ACVRL1, is a type I receptor for TGF-β superfamily with 2 ligands, BMP9 and BMP10. ALK-1 is predominantly expressed in endothelial cells and plays a critical role in regulating developmental and pathological angiogenesis[1][2]. ACVRL1/ALK1 Protein, Mouse (HEK293, His-Fc) is produced in HEK293 cells with a C-Terminal His-tag and a C-Terminal Fc-tag. It consists of 119 amino acids (M1-P119).
- Application
-
Alternative Names
Serine/threonine-protein kinase receptor R3; SKR3; ALK-1; TSR-I; ACVRL1
-
Species
Mouse
-
Source
HEK293
-
Tag
C-hFc;C-His
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
Q61288
-
Expression Region
M1-P119
-
Protein Length
Extracellular Domain
-
Molecular Weight
50-55 kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Related Products
Protein Description
ACVRL1, also known as Activin A Receptor Type II-Like 1, and ALK1, or Activin Receptor-Like Kinase 1, are members of the transforming growth factor-beta (TGF-β) superfamily of receptors. They play a crucial role in vascular development and homeostasis, particularly in angiogenesis and regulation of endothelial cell function. Mutations in the ACVRL1 gene are linked to hereditary hemorrhagic telangiectasia (HHT), a genetic disorder characterized by abnormal blood vessel formation, leading to fragile capillaries and recurrent bleeding. Research on ACVRL1/ALK1 recombinant proteins aims to elucidate their signaling pathways and interactions within the TGF-β superfamily, providing insights into their roles in vascular diseases. Studies have shown that dysregulation of ACVRL1/ALK1 signaling contributes to various pathologies, including HHT and pulmonary arterial hypertension. By investigating these recombinant proteins, researchers seek to develop potential therapeutic strategies that target these pathways, potentially improving treatment options for patients suffering from related vascular disorders. Furthermore, understanding the mechanistic details of ACVRL1/ALK1 function could lead to innovations in regenerative medicine, tissue engineering, and the management of vascular malformations. Through detailed structural and functional characterization, ongoing studies are poised to enhance our knowledge of their biological significance and therapeutic potential.
