Analytical Data
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基因名
PARP2
- Application
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别名
(PARP-2)(hPARP-2)(ADP-ribosyltransferase diphtheria toxin-like 2)(ARTD2)(DNA ADP-ribosyltransferase PARP2)(NAD(+) ADP-ribosyltransferase 2)(ADPRT-2)(Poly[ADP-ribose] synthase 2)(pADPRT-2)(Protein poly-ADP-ribosyltransferase PARP2)
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种属
Human
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表达系统
E. coli
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标签
C- His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9UGN5
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表达区间
233-583aa
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分子量
41.3 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PARP2 (Poly(ADP-ribose) polymerase 2) is a member of the PARP family of enzymes, which play a crucial role in cellular responses to DNA damage and stress, particularly through the post-translational modification of proteins via poly(ADP-ribosyl)ation. Unlike its closely related counterpart PARP1, PARP2 exhibits distinct functions and regulatory mechanisms that contribute to genomic stability and cellular survival. The study of PARP2 has gained significant attention due to its implications in cancer biology; aberrations in its expression or activity can affect tumor progression and response to therapies. Additionally, PARP2 is implicated in various physiological processes, including DNA repair, regulation of gene expression, and modulation of apoptosis. Given the therapeutic potential of targeting PARP enzymes in cancer treatment, the development of detailed structural and functional insights into PARP2 is paramount. Recombinant protein studies of PARP2 allow researchers to elucidate its enzymatic activity, interaction with DNA, and role in the PARP pathway, thus providing valuable information for potential drug development and understanding its contribution to disease mechanisms. These investigations enhance our understanding of PARP2's biological functions and pave the way for novel therapeutic strategies that exploit its activities in cancer and other diseases characterized by DNA repair deficiencies.
