Analytical Data
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Gene name
VEGFR-3/FLT4
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简介
VEGFR-3/FLT4 proteins are tyrosine protein kinase receptors for VEGFC and VEGFD and are critical in adult lymphangiogenesis and embryonic vascular development. It promotes endothelial cell function, angiogenesis, and forms a positive feedback loop that increases VEGFC production. VEGFR-3/FLT4 Protein, Mouse (HEK293, mFc) is the recombinant mouse-derived VEGFR-3/FLT4 protein, expressed by HEK293, with C-mFc labeled tag.
- Application
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Alternative Names
Vascular endothelial growth factor receptor 3; VEGFR-3; FLT-4
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Species
Mouse
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Source
HEK293
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Tag
C-mFc
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P35917
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Expression Region
Y25-E775
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Protein Length
Extracellular Domain
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Molecular Weight
116-125 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
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Protein Description
Vascular endothelial growth factor receptor 3 (VEGFR-3), also known as Flt-4, is a receptor tyrosine kinase primarily involved in lymphangiogenesis and the regulation of lymphatic endothelial cell biology. The significance of VEGFR-3 in angiogenesis, lymphangiogenesis, and immune response has prompted extensive research into its role in various physiological and pathological contexts, particularly in cancer progression and metastasis. Dysregulation of VEGFR-3 signaling is associated with numerous diseases, including tumors that exploit lymphatic pathways for metastasis, underlining the receptor's potential as a therapeutic target. The generation of recombinant VEGFR-3 proteins has enabled detailed studies of its structure-function relationships and interactions with ligands, such as VEGF-C and VEGF-D, which are crucial for understanding its signaling mechanisms. These studies contribute to the development of novel therapeutic strategies aimed at modulating VEGFR-3 activity, offering promising avenues for cancer therapy and lymphatic disease treatment. As such, the investigation of VEGFR-3 recombinant proteins represents a vital area of focus in vascular biology and therapeutic development.
