Analytical Data
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基因名
Amyloid Precursor/APP-695
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简介
Amyloid Precursor/APP-695 Protein, Human (HEK293, Fc) is an Amyloid Precursor (APP) protein with C-Fc. Amyloid Precursor Protein can be used for the study of brain development, learning and memory, synaptic plasticity, and neurodegeneration[1].
- Application
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别名
rHuAmyloid Precursor, C-Fc; Amyloid-Precursor
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种属
Human
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表达系统
HEK293
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标签
C-hFc
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P05067-4
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表达区间
L18-K612
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氨基酸序列
LEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVRVPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEEISEVKMDAEFRHDSGYEVHHQK
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蛋白长度
Partial
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分子量
120-145 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Amyloid Precursor Protein (APP) is a transmembrane protein crucially involved in the pathogenesis of Alzheimer’s disease (AD). The APP gene, located on chromosome 21, is known to undergo proteolytic processing by enzymes such as β-secretase and γ-secretase, resulting in the production of amyloid-beta (Aβ) peptides. These peptides can aggregate and form plaques, which are hallmark features of AD pathology. Research has increasingly focused on elucidating the structure and function of APP-695, the predominant isoform of APP in neurons, as it plays a significant role in neuronal development and synaptic function. Recombinant APP-695 protein has become an important tool for scientists, enabling the study of APP processing, Aβ generation, and the modulation of these pathways by potential therapeutic agents. Understanding the detailed mechanisms of APP-695 can provide insights into the molecular underpinnings of AD and aid in the development of targeted treatments that could modify the disease’s course or prevent its onset. This research is particularly relevant given the aging population and the increasing incidence of neurodegenerative diseases, making the investigation of APP-695 and its associated pathways vital for advancing our understanding and management of Alzheimer's disease.
