Analytical Data
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Gene name
CSNK1G1
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简介
The CSNK1G1 protein is a member of the casein kinase family that preferentially phosphorylates acidic proteins, including casein, exhibiting broad substrate specificity. Functionally, it actively participates in the Wnt signaling pathway and regulates cellular responses. CSNK1G1 Protein, Human (sf9, His-GST) is the recombinant human-derived CSNK1G1 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.
- Application
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Alternative Names
Casein kinase I isoform gamma-1; CKI-gamma 1
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Species
Human
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Source
Baculovirus
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Tag
N-His;N-GST
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9HCP0-1
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Expression Region
M1-K422
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Protein Length
Full Length of Isoform-1
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Molecular Weight
66 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CSNK1G1, or Casein Kinase I Gamma 1, is a serine/threonine kinase involved in crucial cellular processes, including signal transduction, cell cycle regulation, and circadian rhythm modulation. This enzyme is part of the Casein Kinase I family, which plays a significant role in phosphorylating various substrate proteins, thereby influencing their activity, stability, and localization. Studies have indicated that CSNK1G1 is associated with several diseases, including cancer and neurodegenerative disorders, making it a potential therapeutic target. Advances in recombinant protein technology have facilitated the production of CSNK1G1 in heterologous systems, allowing for detailed investigation of its biochemical properties and interactions. Understanding the structure and function of CSNK1G1 through recombinant protein studies can provide insights into its role in cellular signaling pathways and disease mechanisms. Furthermore, the development of specific inhibitors or modulators of CSNK1G1 could open new avenues for intervention in related pathologies. The exploration of this protein's function, dynamics, and regulatory mechanisms remains a critical area of research in molecular biology and pharmacology, highlighting its significance in both basic research and clinical applications.
