Analytical Data
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Gene name
AK1
- Application
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Alternative Names
ATP-AMP transphosphorylase 1
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Species
Human
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Source
E. coli
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Tag
N- His-SUMO
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P00568
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Expression Region
1-194aa
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Molecular Weight
37.6 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The AK1 recombinant protein is derived from the adenosine kinase (AK) family, which plays a crucial role in cellular energy metabolism and nucleotide homeostasis. In particular, AK1 catalyzes the phosphorylation of adenosine to adenosine monophosphate (AMP), influencing various physiological processes, including cellular signaling and neuroprotection. Research into the AK1 protein has gained momentum due to its potential implications in various pathophysiological conditions such as cancer, neurodegenerative diseases, and cardiovascular disorders. Recombinant expression of AK1 allows for detailed studies on its structure-function relationships and enzymatic activity, which are pivotal for understanding its role in health and disease. Moreover, AK1 has been explored as a therapeutic target, as modulating its activity may offer new avenues for treatment strategies. Investigations into the expression levels and activity of AK1 in different tissues have also revealed its significance in developmental biology and organ function. As such, the study of AK1 recombinant protein not only enhances our understanding of adenosine metabolism but also paves the way for innovative therapeutic interventions. This research area highlights the importance of basic biochemistry in translational medicine, bridging fundamental science with potential clinical applications.
