Analytical Data
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Gene name
TAFA4
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简介
TAFA4 protein, a modulator of injury-induced and chemical pain hypersensitivity, influences pain responses. It serves as a ligand for FPR1, chemoattracting macrophages, enhancing phagocytosis, and elevating reactive oxygen species (ROS) release. TAFA4's multifaceted role indicates involvement in immune responses and cellular processes related to inflammation and injury. TAFA4 Protein, Human (His) is the recombinant human-derived TAFA4 protein, expressed by E. coli , with N-6*His labeled tag.
- Application
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Alternative Names
Protein FAM19A4; Chemokine-like protein TAFA-4; TAFA4; family with sequence similarity 19 (chemokine (C-C motif)-like); member A4; FAM19A4; chemokine-like protein TAFA-4
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Species
Human
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Source
E. coli
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Tag
N-6*His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q96LR4
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Expression Region
S35-R140
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Protein Length
Partial
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Molecular Weight
16.0 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TAFA4 is a member of the TAFA family of proteins, which are characterized by their unique structural motifs and are known to play roles in various biological processes. Recent studies have highlighted the potential functions of TAFA4 in modulating immune response, neuronal differentiation, and tissue repair. Its expression pattern is particularly interesting as it is prominently found in the central nervous system and immune cells, suggesting a crucial role in neuroinflammatory conditions and neurodegenerative diseases. The re-engineering of TAFA4 into recombinant proteins has drawn attention for its potential therapeutic applications, especially in the context of neurological disorders. Scholars have focused on understanding the mechanisms by which TAFA4 influences cellular pathways to promote neuroprotection and regenerative processes. Furthermore, characterizing its interactions with other biomolecules aims to elucidate the signaling networks involved, paving the way for novel treatments targeting TAFA4-related pathways. Data pertaining to the structural composition, biological activity, and receptor binding of TAFA4 is essential to fully grasp its function and therapeutic potential. Overall, the research on TAFA4 recombinant proteins represents a promising frontier in biomedical science, with implications for treating diverse conditions linked to immune and neural dysfunctions.
