Analytical Data
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Gene name
SLC22A6
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简介
The SLC22A6 protein acts as a Na(+)-independent organic anion (OA)/dicarboxylic acid antiporter and promotes renal elimination by transporting OA from proximal tubule cells into the urine. It transports coenzymes (BH4, BH2, septopterin) and determines blood biopterin levels as well as prostaglandins, cyclic nucleotides, tryptophan metabolites, uremic toxins (e.g. indoxyl sulfate) and xenobiotics (e.g. ochratoxin). SLC22A6 Protein, Human (Sf9, His, MBP, FLAG) is the recombinant human-derived SLC22A6 protein, expressed by Sf9 insect cells .
- Application
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Alternative Names
SLC22A6; Solute carrier family 22 member 6; Organic anion transporter 1; hOAT1; PAH transporter; hPAHT; Renal organic anion transporter 1; Hroat1
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Species
Human
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Source
HEK293
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Tag
N-His;C-Flag;N-MBP
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q4U2R8-1
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Expression Region
A2-L563
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Protein Length
Partial
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
SLC22A6, also known as Organic Anion Transporter 1 (OAT1), plays a crucial role in the renal excretion of various endogenous and exogenous organic anions, including drugs and metabolic waste products. This transporter is pivotal in pharmacokinetics, influencing drug efficacy and toxicity by modulating the clearance of therapeutic agents from the bloodstream. Mutations or polymorphisms in the SLC22A6 gene can lead to altered transporter function, potentially affecting individual drug response and susceptibility to adverse effects. Given its significance in drug metabolism, researchers have focused on characterizing the SLC22A6 protein to better understand its transport mechanisms, substrate specificity, and regulatory pathways. Additionally, recombinant SLC22A6 protein production enables the investigation of its interactions with various ligands and drugs in vitro, aiding in the elucidation of structure-function relationships. This research also has implications for personalized medicine, as insights gained from SLC22A6 studies may contribute to the optimization of drug dosing regimens based on genetic profiling. Furthermore, the investigation of SLC22A6 is vital for understanding its role in kidney function and disease, as well as developing strategies to mitigate drug-drug interactions that may arise from competition for transport pathways. Overall, the comprehensive study of SLC22A6 as a recombinant protein is essential for advancing our knowledge in pharmacology, toxicology, and clinical therapeutics.
