Analytical Data
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Gene name
MAP3K8/TPL-2
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简介
MAP3K8/TPL-2 is critical for LPS-induced, TLR4-mediated activation of MAPK/ERK, leading to TNF production by macrophages. It regulates T cell differentiation, IFNG expression, and host resistance to bacterial infections by negatively regulating type I interferon production. MAP3K8/TPL-2 Protein, Human (sf9, GST) is the recombinant human-derived MAP3K8/TPL-2 protein, expressed by Sf9 insect cells , with N-GST labeled tag.
- Application
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Alternative Names
Mitogen-activated protein kinase kinase kinase 8; TPL-2; MAP3K8; COT; ESTF
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Species
Human
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Source
Baculovirus
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Tag
N-GST
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P41279
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Expression Region
M30-R397
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Protein Length
Partial
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Molecular Weight
68 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
MAP3K8, also known as TPL-2, is a serine/threonine kinase that plays a crucial role in the regulation of various cellular processes, including inflammation, cell survival, and differentiation. It is part of the mitogen-activated protein kinase (MAPK) signaling pathway, which is pivotal for transmitting extracellular signals to elicit appropriate cellular responses. Recent studies have illuminated the significance of TPL-2 in immune response regulation and its potential role in cancer progression. The reconstitution of TPL-2 protein allows for a deeper understanding of its functional mechanisms and interactions with other signaling molecules. Furthermore, the dysregulation of TPL-2 has been linked to several inflammatory diseases and malignancies, sparking interest in its therapeutic targeting. Researchers aim to develop specific inhibitors or modulators of TPL-2 to explore its potential in treating these conditions. This growing body of evidence underscores the importance of studying MAP3K8/TPL-2, not only to unravel its biological roles but also to harness its potential as a target in disease intervention and drug development.
