Analytical Data
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基因名
Epiregulin
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简介
Epiregulin Protein, a ligand for EGFR and ERBB4, induces their tyrosine phosphorylation, playing a pivotal role in inflammation, wound healing, tissue repair, and oocyte maturation. It regulates angiogenesis, vascular remodeling, and cell proliferation, emphasizing its involvement in intricate cellular signaling pathways. Epiregulin Protein, Mouse (HEK293, hFc) is the recombinant mouse-derived Epiregulin protein, expressed by HEK293 , with N-hFc labeled tag.
- Application
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别名
Proepiregulin; Epiregulin; EPR; EREG
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种属
Mouse
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表达系统
HEK293
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标签
N-hFc
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q61521
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表达区间
V56-L101
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蛋白长度
Full Length of Epiregulin
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分子量
37 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Epiregulin is an EGF (epidermal growth factor) family member that plays a crucial role in cell proliferation, differentiation, and survival. Its function is mediated through binding to EGF receptors, which leads to the activation of various signaling pathways, including the MAPK and PI3K/Akt pathways. Initially discovered in the context of skin epithelial cells, Epiregulin has garnered attention for its potential implications in various pathological conditions, such as cancer and inflammatory diseases. Research has shown that aberrant expression of Epiregulin is associated with tumor progression and metastasis, suggesting that it could serve as a promising biomarker for cancer prognosis. Moreover, studies indicate that Epiregulin may contribute to tissue repair and regeneration, indicating its potential therapeutic applications in regenerative medicine. Given its multifaceted roles, recombinant Epiregulin protein has become a subject of investigation for both basic research and clinical applications. Understanding the detailed mechanisms of Epiregulin's actions can pave the way for the development of targeted therapies aimed at modulating its pathways, offering novel strategies for treating various diseases characterized by dysregulated cell growth and survival. As such, research into recombinant Epiregulin not only enhances our comprehension of cellular signaling mechanisms but also represents a pivotal step toward innovative therapeutic interventions in oncology and regenerative medicine.
