Analytical Data
-
基因名
IBSP
-
简介
The IBSP protein has a strong affinity for hydroxyapatite and plays a crucial role in mineralized matrix formation, indicating its overall nature in this regard. Its tight binding suggests an important role in cell-matrix interactions, particularly in promoting RGD-dependent cell attachment. IBSP Protein, Human (His-SUMO) is the recombinant human-derived IBSP protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
- Application
-
别名
BNSP; Bone sialoprotein 2; Bone sialoprotein II; BSP; BSP II; BSPII; Cell binding sialoprotein; Cell-binding sialoprotein; IBSP; Integrin binding sialoprotein; Integrin-binding sialoprotein; SIAL_HUMAN; SPII
-
种属
Human
-
表达系统
E. coli
-
标签
N-6*His;N-SUMO
-
纯度
Greater than 90% as determined by SDS-PAGE.
-
蛋白编号
P21815
-
表达区间
A129-E281
-
蛋白长度
Partial
-
分子量
40 kDa
-
内毒素
< 1.0 EU per μg protein as determined by the LAL method.
-
性状
Freeze-dried powder
-
缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
-
稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
IBSP (Integrin Binding Sialoglycoprotein) is a cell adhesion molecule that plays a pivotal role in bone biology and the regulation of mineralization. It is primarily expressed by osteoblasts and osteocytes, contributing to bone formation and remodelling through its interactions with integrins and other extracellular matrix components. Recent studies have highlighted the significance of IBSP in various physiological and pathological conditions, including bone diseases such as osteoporosis and metastatic cancer. The recombinant expression of IBSP proteins has become an essential tool for investigating its functional properties and biological mechanisms. By producing IBSP in a recombinant form, researchers can explore its structural characteristics, binding affinities, and interactions with cell surface receptors, facilitating a better understanding of its role in bone health and disease. Additionally, recombinant IBSP can be utilized in therapeutic applications, such as designing biomaterials for bone regeneration and enhancing osteogenic differentiation. Overall, the study of IBSP recombinant proteins provides valuable insights into the molecular underpinnings of bone biology and opens new avenues for developing targeted therapies for skeletal disorders.
