Analytical Data
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Gene name
CSNK1G2
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简介
Casein kinase I gamma-2 is a serine/threonine protein kinase that targets acidic proteins and phosphorylates a variety of substrates, such as COL4A3BP/CERT, MTA1 and SMAD3, especially destabilizing SMAD3 and inhibiting TGF- beta reaction. Hyperphosphorylation of COL4A3BP/CERT disrupts ER-to-Golgi transport and affects the synthesis of ceramide and sphingomyelin. CSNK1G2 Protein, Human (sf9, GST) is the recombinant human-derived CSNK1G2, expressed by Sf9 insect cells, with GST labeled tag. The total length of CSNK1G2 Protein, Human (sf9, GST) is 414 a.a..
- Application
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Alternative Names
CSNK1G2; casein kinase 1 gamma 2; CK1g2
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Species
Human
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Source
Baculovirus
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Tag
GST
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P78368
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Expression Region
D2-K415
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Protein Length
Partial
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
CSNK1G2, or Casein Kinase 1 Gamma 2, is a member of the casein kinase 1 (CK1) family, which is involved in various cellular processes including the regulation of circadian rhythms, Wnt signaling, and the cell cycle. Due to its critical role in these pathways, abnormalities in CSNK1G2 activity are implicated in several pathological conditions, such as cancer and neurodegenerative disorders. Recently, research has focused on the structural and functional characterization of CSNK1G2 to understand its mechanisms of action at the molecular level. Recombinant CSNK1G2 protein has been produced to facilitate in vitro studies, enabling researchers to analyze its enzymatic activity, substrate specificity, and interaction with regulatory proteins. This has proven essential for deciphering the intricate regulatory networks in which CSNK1G2 is involved, potentially leading to the identification of novel therapeutic targets. The generation of high-quality recombinant CSNK1G2 protein lays the foundation for further functional assays and structure-based drug design, aiming to modulate its activity in disease contexts. Insights gained from these studies could contribute to the development of targeted therapies, providing promising avenues for the treatment of diseases associated with CK1 dysfunction.
