Analytical Data
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基因名
AURKA
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简介
AURA is a mitotic serine/threonine kinase that complexly controls cell cycle progression and various mitotic events. AURA associates with centrosomes and spindle microtubules during mitosis and plays a critical role in spindle establishment, centrosome duplication, chromosome alignment, spindle assembly checkpoint activation, and cytokinesis. AURKA Protein, Human (sf9, GST) is the recombinant human-derived AURKA, expressed by Sf9 insect cells, with GST labeled tag. The total length of AURKA Protein, Human (sf9, GST) is 402 a.a..
- Application
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别名
AURKA; aurora kinase A; AIK; ARK1; AURA; BTAK; STK6; STK7; STK15; PPP1R47
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种属
Human
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表达系统
Baculovirus
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标签
GST
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O14965
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表达区间
D2-S403
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蛋白长度
Full Length
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Aurora A kinase (AURKA) is a crucial mitotic serine/threonine kinase that plays a significant role in cell division, particularly in processes such as spindle assembly, centrosome maturation, and chromosome alignment. Aberrant regulation of AURKA has been implicated in various cancers, making it a valuable target for therapeutic interventions. The study of recombinant AURKA protein has become increasingly important for understanding its molecular mechanisms and functions. By producing AURKA in a recombinant form, researchers can investigate its biochemical properties, post-translational modifications, and interactions with other proteins in a controlled environment. This enables the elucidation of AURKA’s role in tumorigenesis and its potential as a drug target. Furthermore, recombinant AURKA is utilized in high-throughput screening assays for identifying small-molecule inhibitors that could serve as novel cancer therapies. The ongoing research on AURKA not only contributes to the basic understanding of cell cycle regulation but also paves the way for the development of targeted treatments, highlighting its dual significance in both fundamental biology and clinical applications.
