Analytical Data
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基因名
cIAP1/BIRC2
- Application
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别名
API1; HIAP2; Hiap-2; MIHB; RNF48; cIAP1; Inhibitor of apoptosis protein 2; NFR2-TRAF Signalling Complex Protein; Apoptosis Inhibitor 1
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种属
Human
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表达系统
E. coli
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标签
N- His & GST
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纯度
Greater than 95% as determined by SDS-PAGE.
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蛋白编号
Q13490
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表达区间
Phe344~Gln593
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分子量
58kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
cIAP1 (Cellular Inhibitor of Apoptosis Protein 1), also known as BIRC2 (Baculoviral IAP Repeat Containing 2), is a critical regulator of apoptosis and cell survival, playing a key role in cancer biology. It belongs to the inhibitor of apoptosis protein (IAP) family, which is characterized by the presence of baculoviral IAP repeats that facilitate its anti-apoptotic functions. cIAP1 is known to promote cell proliferation and inhibit programmed cell death, making it a significant factor in tumorigenesis and cancer progression. Research has shown that cIAP1/BIRC2 is often overexpressed in various malignancies and contributes to chemoresistance, presenting it as a potential therapeutic target. The study of its recombinant protein allows for a deeper understanding of its structural and functional properties, enabling the exploration of its interactions with other cellular molecules and signaling pathways. This protein has garnered attention in drug development, particularly in the design of inhibitors that can selectively disrupt its anti-apoptotic functions, thus restoring the apoptotic response in cancer cells. Additionally, investigations into cIAP1's role in immune regulation and inflammation further underscore its importance in both tumor biology and therapeutic interventions. Overall, cIAP1/BIRC2 represents a fascinating and vital component in the complexity of cancer mechanisms, making it a subject of intense scientific inquiry aimed at developing novel treatment strategies.
