Analytical Data
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基因名
Tubulin cofactor A
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简介
The tubulin cofactor A protein is a key tubulin folding protein that initiates the tubulin folding pathway within the supercomplex (cofactors A to E). Cofactors A and D capture tubulin and stabilize it in a quasi-native state. Tubulin cofactor A Protein, Human (Tag Free) is the recombinant human-derived Tubulin cofactor A protein, expressed by E. coli , with tag free.
- Application
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别名
Tubulin-specific chaperone A; CFA; TBCA
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种属
Human
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表达系统
E. coli
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标签
Tag Free
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纯度
Greater than 95% as determined by SDS-PAGE.
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蛋白编号
O75347
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表达区间
M1-A108
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蛋白长度
Full Length
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分子量
14 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Tubulin cofactor A (TBCoA) plays a crucial role in the assembly of microtubules, which are vital components of the cytoskeleton involved in various cellular processes, including cell division, intracellular transport, and maintaining cell shape. Microtubules are polymeric structures composed of α- and β-tubulin dimers, and their proper formation is essential for normal cellular function. TBCoA assists in the incorporation of tubulin dimers into the growing microtubule structure, regulating their stability and dynamics. Research on recombinant TBCoA has gained importance due to its potential implications in understanding diseases linked to microtubule dysfunction, such as cancer and neurodegenerative disorders. By studying the recombinant form of TBCoA, researchers aim to elucidate its structural and functional properties, which may provide insights into the molecular mechanisms governing microtubule assembly and disassembly. Additionally, understanding TBCoA interactions with other cofactors and tubulin can lead to the development of novel therapeutics that target the microtubule system in pathological conditions. Ultimately, the study of recombinant tubulin cofactor A not only enhances our comprehension of fundamental cellular processes but also opens avenues for biomedical applications in treating diseases where microtubule dynamics are disrupted.
