Analytical Data
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基因名
Cyclophilin F/PPIF 蛋白
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简介
Cyclophilin F/PPIF protein is a peptidyl prolyl cis-trans isomerase (PPIase) that catalyzes the isomerization of proline imide peptide bonds and may contribute to protein folding. It critically regulates the mitochondrial permeability transition pore (mPTP), affecting cell apoptosis or necrosis. Cyclophilin F/PPIF Protein, Human (HEK293, His, solution) is the recombinant human-derived Cyclophilin F/PPIF protein, expressed by HEK293 , with C-His labeled tag.
- Application
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别名
Peptidyl-prolyl cis-trans isomerase; PPIase; PPIF
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种属
Human
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表达系统
HEK293
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标签
C-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P30405
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表达区间
C30-S207
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蛋白长度
Full Length of Mature Protein
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分子量
20.3 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Cyclophilin F (CYPF), also known as peptidyl-prolyl isomerase F (PPIF), is a member of the cyclophilin family of proteins, which play critical roles in protein folding, signal transduction, and cellular stress responses. CYPF is particularly notable for its involvement in various cellular processes, including apoptosis, immunological responses, and mitochondrial function. Its isomerase activity facilitates the folding of polypeptides, contributing to proper protein conformation and function. Research has shown that CYPF is implicated in several diseases, including cancer and neurodegenerative disorders, linking its dysfunction to various pathological conditions. The recombinant expression of CYPF allows for detailed studies of its biochemical properties and functional roles, providing valuable insights into its mechanism of action. Furthermore, understanding the structure and function of CYPF through recombinant technology can aid in the development of therapeutic strategies targeting its pathways. Given its involvement in critical cellular processes and potential as a drug target, the study of recombinant CYPF not only enhances our fundamental understanding of protein biology but also opens avenues for therapeutic intervention in diseases where CYPF is implicated.
