Analytical Data
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基因名
beta-Catenin
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简介
β-Catenin is a key component of canonical Wnt signaling, which dynamically controls cellular processes. In the absence of Wnt, it forms a complex leading to phosphorylation and degradation. beta-Catenin Protein, Mouse (sf9, His-GST) is the recombinant mouse-derived beta-Catenin protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.
- Application
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别名
beta-Catenin; Catenin beta-1; CTNNB; CTNNB1
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种属
Mouse
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表达系统
Baculovirus
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标签
N-His;N-GST
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q02248
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表达区间
M1-L781
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蛋白长度
Full Length
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分子量
115 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Beta-catenin is a crucial component of the Wnt signaling pathway, which plays a significant role in cell-cell adhesion and the regulation of gene transcription associated with cell proliferation and differentiation. Dysregulation of beta-catenin has been linked to various diseases, particularly cancer, making it a focal point in research aimed at understanding tumorigenesis and potential therapeutic interventions. The study of recombinant beta-catenin proteins has gained importance as these proteins can be used to investigate the molecular mechanisms governing Wnt signaling and its implications in developmental biology and oncogenesis. By producing recombinant beta-catenin in various systems, researchers can explore its functional properties, interaction with other cellular partners, and the effects of post-translational modifications. This research provides insights into the differential roles beta-catenin plays in normal physiology versus pathological states, thereby enhancing our knowledge of targeted therapies in cancers where beta-catenin is aberrantly activated. Additionally, such studies facilitate the development of small molecules or biologics that can modulate the Wnt/beta-catenin pathway, offering promising avenues for therapeutic exploitation in diseases characterized by its dysregulation. The understanding gained from beta-catenin recombinant protein research is vital for the advancement of precision medicine and the design of innovative treatment strategies tailored to target Wnt-related diseases.
