Analytical Data
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基因名
TPM1
- Application
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别名
Alpha-tropomyosin Tropomyosin-1 TPMA
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种属
Rabbit
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表达系统
E. coli
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标签
N- His & C- Myc
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P58772
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表达区间
1-284aa
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分子量
37.7 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TPM1 (Tropomyosin 1) is a key protein that plays a crucial role in the regulation of muscle contraction and cytoskeletal organization. It is a part of the tropomyosin family, which is essential for maintaining the stability and functionality of actin filaments in various cell types, including muscle cells, fibroblasts, and neurons. The study of recombinant TPM1 proteins is significant due to their potential implications in understanding various muscle disorders and cardiac diseases linked to mutations in the TPM1 gene. These mutations can lead to disruptions in muscle function, resulting in conditions such as familial hypertrophic cardiomyopathy and skeletal myopathies. By producing recombinant TPM1 proteins, researchers can explore the biophysical properties, binding interactions, and functional dynamics of this protein, providing insights into how alterations in TPM1 affect muscle mechanics at a molecular level. Furthermore, recombinant TPM1 can be utilized in drug screening and the development of therapeutic proteins aimed at rescuing function in affected patients, making it a valuable target in both fundamental research and clinical applications. The increasing advances in protein expression technology, coupled with high-throughput screening techniques, have paved the way for more in-depth studies into the structure-function relationships of TPM1, thus enhancing our understanding of its role in health and disease.












