Analytical Data
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基因名
FLRT2
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简介
The FLRT2 protein plays a key role in cell-cell adhesion, migration, and axonal guidance. Its interaction with ADGRL3 promotes cell-cell adhesion and promotes cortical neuronal migration through interaction with UNC5D. FLRT2 Protein, Mouse (HEK293, His) is the recombinant mouse-derived FLRT2 protein, expressed by HEK293 , with C-His labeled tag.
- Application
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生物活性
Measured by the ability of the immobilized protein to support the adhesion of Neuro-2A mouse neuroblastoma cells. The ED50 for this effect is 0.8205 µg/mL, corresponding to a specific activity is 1.219×103 units/mg. Measured by the ability of the immobilized protein to support the adhesion of Neuro-2A mouse neuroblastoma cells. The ED50 for this effect is 0.8205 µg/mL, corresponding to a specific activity is 1.219×103 units/mg.
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别名
Leucine-rich repeat transmembrane protein FLRT2; Flrt2; Kiaa0405
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种属
Mouse
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表达系统
HEK293
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标签
C-10*His
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纯度
Greater than 95% as determined by SDS-PAGE.
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蛋白编号
Q8BLU0
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表达区间
C36-S539
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氨基酸序列
CPSVCRCDRNFVYCNERSLTSVPLGIPEGVTVLYLHNNQINNAGFPAELHNVQSVHTVYLYGNQLDEFPMNLPKNVRVLHLQENNIQTISRAALAQLLKLEELHLDDNSISTVGVEDGAFREAISLKLLFLSKNHLSSVPVGLPVDLQELRVDENRIAVISDMAFQNLTSLERLIVDGNLLTNKGIAEGTFSHLTKLKEFSIVRNSLSHPPPDLPGTHLIRLYLQDNQINHIPLTAFANLRKLERLDISNNQLRMLTQGVFDHLSNLKQLTARNNPWFCDCSIKWVTEWLKYIPSSLNVRGFMCQGPEQVRGMAVRELNMNLLSCPTTTPGLPVFTPAPSTVSPTTQSPTLSVPSPSRGSVPPAPTPSKLPTIPDWDGRERVTPPISERIQLSIHFVNDTSIQVSWLSLFTVMAYKLTWVKMGHSLVGGIVQERIVSGEKQHLSLVNLEPRSTYRICLVPLDAFNYRTVEDTICSEATTHASYLNNGSNTASSHEQTTSHSMGS
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蛋白长度
Extracellular Domain
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分子量
60-80 kDa.
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
FLRT2 (Fibronectin Leucine-rich Transmembrane Protein 2) is a member of the FLRT family, which plays a critical role in cell adhesion and signaling, influencing various biological processes such as neuronal development, tissue morphogenesis, and immune response. The research background of FLRT2 focuses on its function in regulating synaptic development and plasticity in the nervous system, particularly in the context of homeostasis and adaptation during neural circuit formation. FLRT2 interacts with other adhesion molecules and signaling pathways, including the Rho GTPase family, thereby modulating cytoskeletal dynamics and influencing cell movement and morphology. Studies have indicated that FLRT2 is involved in the modulation of synaptic connections, making it a potential candidate for understanding neurodevelopmental disorders and neurodegenerative diseases. The characterization of FLRT2 as a recombinant protein allows researchers to investigate its structural properties and binding interactions in vitro, leading to insights into its mechanistic roles. Furthermore, understanding FLRT2's interactions and pathways may offer therapeutic avenues for conditions impacted by its dysregulation, highlighting the importance of continued research in this area to elucidate its contributions at the cellular and organismal levels.
