Analytical Data
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Gene name
HBP1
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简介
HBP1 is a transcriptional repressor that regulates target genes by binding specifically to promoter regions, specifically favoring the sequence 5'-TTCATTCATTCA-3'.Its key role in the cell cycle and Wnt pathway involves promoting enhanced binding to the histone H1.0 promoter through the RB1 interaction.HBP1 Protein, Human (His) is the recombinant human-derived HBP1 protein, expressed by E.coli , with N-His labeled tag.
- Application
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Alternative Names
HMG box-containing protein 1; HBP1
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 95% as determined by SDS-PAGE.
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Uniprot
O60381
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Expression Region
P208-F345
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Protein Length
Partial
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Molecular Weight
17 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
HBP1 (HMG-box transcription factor 1) is a crucial protein involved in various cellular processes, including cell differentiation, proliferation, and apoptosis. It plays a significant role in developmental biology and has been linked to the regulation of gene expression in response to environmental signals. Research has indicated that HBP1 may be involved in several physiological and pathological conditions, including cancer and metabolic disorders. The recombinant expression of HBP1 protein is essential for understanding its functional mechanisms and interactions within the cellular context. By using recombinant DNA technology, researchers can produce HBP1 in sufficient quantities to investigate its structural properties and biological functions. This recombinant protein can be utilized in various assays, such as binding studies, protein-protein interaction assays, and functional experiments. Moreover, the production of HBP1 as a recombinant protein allows for the exploration of its potential as a therapeutic target or biomarker in diseases where its expression is dysregulated. The study of HBP1 also contributes to the broader understanding of transcriptional regulation and its implications in health and disease. Overall, the investigation of recombinant HBP1 protein is pivotal in unraveling its biological significance and developing novel therapeutic strategies.
