Analytical Data
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Gene name
VAMP3
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简介
VAMP3 protein is an important SNARE protein that promotes vesicle transport from late endosomes to the trans-Golgi network. Its interaction with BVES, mediated by its C-terminal cytoplasmic tail, is crucial in this process. VAMP3 Protein, Human (His) is the recombinant human-derived VAMP3 protein, expressed by E. coli , with N-His labeled tag.
- Application
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Alternative Names
Vesicle-associated membrane protein 3; VAMP-3; Cellubrevin; CEB; Synaptobrevin-3; VAMP3; SYB3
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Species
Human
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Source
E. coli
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Tag
N-10*His
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Purity
Greater than 95% as determined by SDS-PAGE.
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Uniprot
Q15836
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Expression Region
M1-K77
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Protein Length
Partial
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Molecular Weight
12 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
VAMP3 (Vesicle-associated Membrane Protein 3) is a key player in the cellular vesicle trafficking process, specifically involved in the fusion of vesicles with target membranes. It belongs to the synaptobrevin/VAMP family and is primarily found in neurons and various non-neuronal cells. The understanding of VAMP3's role has been significantly advanced by studies focusing on its structure and function in neurotransmitter release and membrane dynamics. In recent years, researchers have investigated the potential of VAMP3 as a therapeutic target in neurodegenerative diseases and other conditions linked to impaired vesicle trafficking. The production of recombinant VAMP3 protein has enabled detailed studies of its molecular interactions and functional mechanisms, facilitating the exploration of its involvement in essential processes such as exocytosis and endocytosis. Recombinant VAMP3 protein serves as a valuable tool in elucidating the pathways of intracellular transport and offers insights into the development of strategies aimed at modulating vesicle-mediated release in both physiological and pathological contexts. Overall, the research surrounding VAMP3 continues to unveil its critical functions in cell biology, highlighting its potential as a biomarker or therapeutic target in various diseases characterized by disrupted vesicle trafficking.
