Analytical Data
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Gene name
CLSTN1
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简介
The CLSTN1 protein acts as a postsynaptic adhesion molecule and promotes excitatory and inhibitory synapse formation by binding to presynaptic neurotoxins.It acts as a cell adhesion molecule on the postsynaptic membrane and forms an association with neurotoxin-α on the presynaptic membrane.CLSTN1 Protein, Human (HEK293, His) is the recombinant human-derived CLSTN1 protein, expressed by HEK293 , with C-His labeled tag.
- Application
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Alternative Names
Calsyntenin-1; Alcadein-alpha; SAlc-alpha; CTF1-alpha; CS1; KIAA0911
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Species
Human
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Source
HEK293
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Tag
C-10*His
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Purity
Greater than 95% as determined by SDS-PAGE.
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Uniprot
O94985-1
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Expression Region
A29-T859
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AA Sequence
ARVNKHKPWLEPTYHGIVTENDNTVLLDPPLIALDKDAPLRFAESFEVTVTKEGEICGFKIHGQNVPFDAVVVDKSTGEGVIRSKEKLDCELQKDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVNDVNEYAPVFKEKSYKATVIEGKQYDSILRVEAVDADCSPQFSQICSYEIITPDVPFTVDKDGYIKNTEKLNYGKEHQYKLTVTAYDCGKKRATEDVLVKISIKPTCTPGWQGWNNRIEYEPGTGALAVFPNIHLETCDEPVASVQATVELETSHIGKGCDRDTYSEKSLHRLCGAAAGTAELLPSPSGSLNWTMGLPTDNGHDSDQVFEFNGTQAVRIPDGVVSVSPKEPFTISVWMRHGPFGRKKETILCSSDKTDMNRHHYSLYVHGCRLIFLFRQDPSEEKKYRPAEFHWKLNQVCDEEWHHYVLNVEFPSVTLYVDGTSHEPFSVTEDYPLHPSKIETQLVVGACWQEFSGVENDNETEPVTVASAGGDLHMTQFFRGNLAGLTLRSGKLADKKVIDCLYTCKEGLDLQVLEDSGRGVQIQAHPSQLVLTLEGEDLGELDKAMQHISYLNSRQFPTPGIRRLKITSTIKCFNEATCISVPPVDGYVMVLQPEEPKISLSGVHHFARAASEFESSEGVFLFPELRIISTITREVEPEGDGAEDPTVQESLVSEEIVHDLDTCEVTVEGEELNHEQESLEVDMARLQQKGIEVSSSELGMTFTGVDTMASYEEVLHLLRYRNWHARSLLDRKFKLICSELNGRYISNEFKVEVNVIHTANPMEHANHMAAQPQFVHPEHRSFVDLSGHNLANPHPFAVVPST
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Protein Length
Extracellular Domain
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Molecular Weight
95-130 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
CLSTN1, or Calsyntenin-1, is a member of the calsyntenin family of proteins, which are involved in various cellular processes including synaptic function and neuronal development. Research on CLSTN1 has gained momentum due to its potential roles in the central nervous system, particularly in synaptic signaling and neurotransmitter release. It has been implicated in neurodevelopmental disorders and neurodegenerative diseases, making it a target of interest for understanding the molecular mechanisms underlying these conditions. The production and characterization of recombinant CLSTN1 protein enable researchers to investigate its structural properties, functional roles, and interactions with other biomolecules. Additionally, studying CLSTN1 in a recombinant form can facilitate the development of therapeutic strategies aimed at modulating its function in disease contexts. Overall, the exploration of CLSTN1 as a recombinant protein provides crucial insights into the biology of neuronal signaling and highlights its potential as a biomarker or therapeutic target in neurological research.
